Description

cis-1-Amino-Indan-2-Carboxylic Acid is a high-purity, non-proteinogenic amino acid derivative featuring a rigid indane scaffold. This compound is a critical chiral building block in modern pharmaceutical synthesis, valued for its ability to introduce conformational constraint into peptide backbones and small molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in areas such as protease inhibitors, receptor modulators, and diagnostic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptidomimetics and active pharmaceutical ingredients (APIs).
• Protease Inhibitor Development: Used in the research and production of inhibitors for enzymes like renin, HIV protease, and thrombin.
• Conformationally Constrained Peptide Analogues: Serves as a backbone modification to enhance metabolic stability, potency, and selectivity of peptide-based drugs.
• Chemical Biology & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and as a scaffold in combinatorial chemistry libraries.
• Diagnostic Agent Synthesis: Potential use in creating labeled compounds for imaging and diagnostic applications.
• Academic & Industrial Research: A valuable reagent for exploring novel bioisosteres and pharmacophores in drug discovery programs.

Basic Information

Product Name	cis-1-Amino-Indan-2-Carboxylic Acid
CAS No.	135053-20-2
Molecular Formula	C10H11NO2
Molecular Weight	177.20 g/mol
Synonyms	(1S,2R)-1-Amino-2,3-dihydro-1H-indene-2-carboxylic acid; (1S,2R)-1-Aminoindane-2-carboxylic acid; cis-1-AIC; cis-Aminoindan-2-carboxylic Acid; (1S,2R)-AIC; 1-Amino-2-carboxyindan (cis); L-AIC (cis); AIDA (cis isomer)
EINECS	Contact for details

Quality Control

Our cis-1-Amino-Indan-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical research and development. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.