Description

Bicyclo[3.1.0]Hexan-3-Ol, 1-Ethynyl-2-Methylene-, [1S-(1Alpha,3Alpha,5Alpha)]- (9Ci) is a high-purity, stereochemically defined bicyclic organic compound featuring a unique combination of an ethynyl and a methylene group on a strained ring system. This compound matters as a sophisticated chiral building block and key synthetic intermediate, enabling the construction of complex molecular architectures with precise three-dimensional control. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for advanced synthesis, particularly in the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting CNS disorders and other therapeutic areas.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where its rigid, functionalized core can contribute to unique biological activity.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials with tailored properties.
• Asymmetric Catalysis Ligand Scaffold: Provides a structurally complex framework for the design and synthesis of novel chiral ligands and organocatalysts.
• Academic & R&D Laboratories: Employed in fundamental organic chemistry research to study strained ring reactions, cycloadditions, and novel synthetic methodologies.
• Fine Chemical Synthesis: Utilized in the multi-step synthesis of complex natural products, flavors, and fragrances requiring high stereochemical fidelity.

Basic Information

Product Name	Bicyclo[3.1.0]Hexan-3-Ol, 1-Ethynyl-2-Methylene-, [1S-(1Alpha,3Alpha,5Alpha)]- (9Ci)
CAS No.	135041-02-0
Molecular Formula	C9H10O
Molecular Weight	134.18 g/mol
Synonyms	(1S,3S,5S)-1-Ethynyl-2-methylidenebicyclo[3.1.0]hexan-3-ol; [1S-(1α,3α,5α)]-1-Ethynyl-2-methylenebicyclo[3.1.0]hexan-3-ol; 1-Ethynyl-2-methylenebicyclo[3.1.0]hexan-3-ol, (1S,3S,5S)-; Bicyclo[3.1.0]hexan-3-ol, 1-ethynyl-2-methylene-, (1S,3S,5S)-; 135041-02-0; (1α,3α,5α)-1-Ethynyl-2-methylenebicyclo[3.1.0]hexan-3-ol
EINECS	Contact for details

Quality Control

Our Bicyclo[3.1.0]Hexan-3-Ol, 1-Ethynyl-2-Methylene-, [1S-(1Alpha,3Alpha,5Alpha)]- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure compliance with exacting R&D and process chemistry standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at 2-8°C under an inert atmosphere. The compound is moisture-sensitive; ensure the container is sealed in a dry environment. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.