Description

Piperazine-2,2,3,3,5,5,6,6-D8 is a deuterium-labeled isotopologue of piperazine, a versatile heterocyclic amine. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring analytical accuracy and reliability. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry industries for drug metabolism studies, pharmacokinetic research, and environmental fate analysis.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of piperazine and its derivatives in complex biological matrices like plasma, urine, and tissue homogenates.
• Pharmaceutical Research & Development: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion (ADME) of active pharmaceutical ingredients.
• Metabolite Identification: Aids in the structural elucidation of drug metabolites by providing a distinct mass spectrometric signature.
• Environmental and Food Safety Analysis: Enables accurate monitoring and quantification of piperazine-based compounds or contaminants in environmental samples and food products.
• Synthesis of Labeled Compounds: Serves as a deuterated building block for the synthesis of more complex isotopically labeled molecules for research.
• Proteomics and Biomarker Discovery: Can be employed in quantitative proteomics workflows for relative and absolute protein quantification.

Basic Information

Item	Detail
Product Name	Piperazine-2,2,3,3,5,5,6,6-D8
CAS No.	134628-42-5
Molecular Formula	C4H2D8N2
Molecular Weight	92.18 g/mol
Synonyms	Perdeuterated Piperazine (d8); Piperazine-d8; Hexadeutero-piperazine; 1,4-Diazacyclohexane-2,2,3,3,5,5,6,6-d8; Diethylenediamine-d8; [2H8]-Piperazine; Deuterated Piperazine Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Piperazine-2,2,3,3,5,5,6,6-D8 is produced and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, verified by advanced analytical techniques including NMR (1H, 13C) and Mass Spectrometry. A comprehensive Certificate of Analysis (COA), detailing assay, isotopic enrichment (D-atom %), and impurity profile, is provided with each shipment to ensure it meets the exacting standards required for analytical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.