Description

(1R,5S,6R)-3-tert-Butyl 6-Ethyl 3-Azabicyclo[3.1.0]Hexane-3,6-Dicarboxylate CAS NO 134575-37-4 is a high-purity, advanced pharmaceutical intermediate featuring a rigid, strained bicyclic scaffold. This compound is a critical chiral building block for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of novel therapeutics targeting the central nervous system and other disease areas. It is essential for research and development organizations, process chemists, and manufacturers in the pharmaceutical and fine chemical industries seeking to build sophisticated molecular architectures with precise stereochemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly those with constrained, three-dimensional structures.
• API Development: Serves as a core building block for the construction of novel Active Pharmaceutical Ingredients (APIs) in preclinical and clinical development pipelines.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new chemical space and optimize drug-like properties.
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce the (1R,5S,6R) configuration into target molecules.
• Process Chemistry & Scale-up: A validated intermediate for the development of robust, scalable manufacturing routes for pharmaceutical production.
• Fine Chemical Synthesis: Employed in the preparation of other specialty chemicals and complex organic molecules requiring its unique bicyclo[3.1.0]hexane framework.

Basic Information

Product Name	(1R,5S,6R)-3-tert-Butyl 6-Ethyl 3-Azabicyclo[3.1.0]Hexane-3,6-Dicarboxylate
CAS No.	134575-37-4
Molecular Formula	C15H25NO4
Molecular Weight	283.36 g/mol
Synonyms	3-(1,1-Dimethylethyl) 6-ethyl 3-azabicyclo[3.1.0]hexane-3,6-dicarboxylate, (1R,5S,6R)-; tert-Butyl 6-ethyl 3-azabicyclo[3.1.0]hexane-3,6-dicarboxylate; 3-Azabicyclo[3.1.0]hexane-3,6-dicarboxylic acid, 3-(1,1-dimethylethyl) 6-ethyl ester, (1R,5S,6R)-; Bicyclo[3.1.0]hexane intermediate; Chiral azabicyclohexane derivative; (1R,5S,6R)-3-Boc-6-ethyl 3-azabicyclo[3.1.0]hexane-6-carboxylate
EINECS	Contact for details

Quality Control

Our production of (1R,5S,6R)-3-tert-Butyl 6-Ethyl 3-Azabicyclo[3.1.0]Hexane-3,6-Dicarboxylate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC to confirm enantiomeric purity and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing purity, chiral assay, and impurity profiles are provided to ensure the material meets the exacting standards required for pharmaceutical R&D and cGMP manufacturing. Specifications can be developed in alignment with client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.