Description

1,1,1-Trifluoro-2-Phenyl-3-Buten-2-Ol is a versatile fluorinated organic building block characterized by a unique combination of a phenyl ring, a trifluoromethyl group, and an allylic alcohol moiety. This compound matters for its role as a key intermediate in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where the introduction of fluorine atoms is crucial for modulating biological activity, metabolic stability, and lipophilicity. It is primarily needed by R&D chemists and process development scientists working on novel active ingredients, specialty polymers, and advanced materials.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of fluorinated drug candidates, including protease inhibitors, kinase inhibitors, and CNS-active compounds.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where fluorine substitution enhances efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Specialty Polymer Modifier: Incorporated into polymer chains to impart specific properties such as chemical resistance, thermal stability, or altered surface energy.
• Asymmetric Catalysis & Ligand Synthesis: Utilized as a chiral pool starting material or precursor for novel ligands in catalytic processes.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new C-F bond formation reactions and fluorinated molecular architectures.

Basic Information

Product Name	1,1,1-Trifluoro-2-Phenyl-3-Buten-2-Ol
CAS No.	134418-70-5
Molecular Formula	C10H9F3O
Molecular Weight	202.17 g/mol
Synonyms	α-(Trifluoromethyl)-β-vinylbenzenemethanol; 2-Phenyl-1,1,1-trifluoro-3-buten-2-ol; 3-Buten-2-ol, 1,1,1-trifluoro-2-phenyl-; 1,1,1-Trifluoro-2-phenylbut-3-en-2-ol; 2-Phenyl-4,4,4-trifluorobut-3-en-2-ol; TFPO; (2-Phenyl-3-buten-2-yl) trifluoromethyl alcohol
EINECS	Contact for details

Quality Control

Our 1,1,1-Trifluoro-2-Phenyl-3-Buten-2-Ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality parameters. Our production adheres to cGMP principles where applicable, ensuring reliability for sensitive pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.