Description

3-(Trimethylsilyl)Pyridin-2-Yl Trifluoromethanesulfonate 95% is a high-purity organosilicon reagent and a versatile triflate ester derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its dual functionality, where the trimethylsilyl group acts as a protective or directing moiety and the triflate group serves as an excellent leaving group for cross-coupling reactions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries, enabling the precise construction of complex heterocyclic frameworks and functionalized pyridine derivatives.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs containing functionalized pyridine or bipyridine cores.
• Cross-Coupling Reactions: Serves as an excellent electrophile in palladium-catalyzed reactions such as Suzuki-Miyaura, Stille, and Negishi couplings to form biaryl and heteroaryl structures.
• Ligand Synthesis: Used in the preparation of sophisticated nitrogen-containing ligands for catalysis and coordination chemistry.
• Material Science Research: Employed in the development of organic semiconductors, conductive polymers, and metal-organic frameworks (MOFs) with tailored electronic properties.
• Agrochemical Development: Acts as a building block for creating novel herbicides, fungicides, and insecticides with pyridine-based architectures.
• Protecting Group Strategy: The trimethylsilyl group can be used for the temporary protection of sensitive functional groups during multi-step synthetic sequences.

Basic Information

Product Name	3-(Trimethylsilyl)Pyridin-2-Yl Trifluoromethanesulfonate 95%
CAS No.	134391-76-7
Molecular Formula	C9H12F3NO3SSi
Molecular Weight	299.35 g/mol
Synonyms	2-Pyridyl Triflate, 3-Trimethylsilyl Derivative; 3-Trimethylsilyl-2-pyridyl Trifluoromethanesulfonate; 3-TMS-2-PyOTf; 2-(Trifluoromethanesulfonyloxy)-3-(trimethylsilyl)pyridine; N/A
EINECS	Contact for details

Quality Control

Our 3-(Trimethylsilyl)Pyridin-2-Yl Trifluoromethanesulfonate 95% is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.