Description

6-Hydroxy-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid Hydrate is a specialized heterocyclic carboxylic acid derivative of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and key intermediate for the development of complex pharmaceutical molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical industries engaged in the synthesis of active pharmaceutical ingredients (APIs) and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly those targeting neurological and cardiovascular systems.
• Organic Synthesis Building Block: Used for constructing isoquinoline-based frameworks and other fused heterocyclic systems in medicinal chemistry research.
• Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic pathways and developing novel chemical entities.
• Precursor for Alkaloid Analogues: Serves as a starting material for the synthesis of tetrahydroisoquinoline alkaloid analogues with potential biological activity.
• Ligand Synthesis: Can be utilized in the preparation of chiral ligands for asymmetric catalysis.

Basic Information

Product Name	6-Hydroxy-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid Hydrate
CAS No.	134388-87-7
Molecular Formula	C10H11NO3 · xH2O
Molecular Weight	193.20 (Anhydrous basis)
Synonyms	6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrate; 3-Carboxy-6-hydroxy-1,2,3,4-tetrahydroisoquinoline hydrate; 6-Hydroxy-3-isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-, hydrate; THIQ-3-COOH-6-OH hydrate; 6-Hydroxy-THIQ-3-carboxylic acid hydrate
EINECS	Contact for details

Quality Control

Our 6-Hydroxy-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid Hydrate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.