Description

Ethyl 6-Hydroxy-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylate is a high-purity, synthetically valuable heterocyclic building block. This compound is a key chiral intermediate in the synthesis of complex pharmaceutical molecules, particularly those targeting the central nervous system. It is essential for research and development chemists and manufacturers in the pharmaceutical and fine chemical industries seeking to develop new therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of potent alkaloids and other bioactive molecules.
• Neurological Research: Used in the development of compounds for studying and treating neurological disorders.
• Asymmetric Synthesis: Serves as a versatile precursor in catalytic asymmetric reactions to create complex stereocenters.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Fine Chemical Production: Used in the custom synthesis of high-value, specialized chemicals for advanced applications.
• Academic & Industrial R&D: A valuable reagent for exploratory chemistry in both university and corporate research laboratories.

Basic Information

Product Name	Ethyl 6-Hydroxy-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylate
CAS No.	134388-85-5
Molecular Formula	C₁₂H₁₅NO₃
Molecular Weight	221.25 g/mol
Synonyms	Ethyl 6-hydroxy-3,4-dihydro-1H-isoquinoline-3-carboxylate; 6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid ethyl ester; (R/S)-Ethyl 6-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate; 6-Hydroxy-THIQ-3-COOEt; 134388-85-5; Ethyl 6-hydroxy-3,4-dihydroisoquinoline-3-carboxylate; 6-Hydroxytetrahydroisoquinoline-3-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 6-Hydroxy-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and impurity profile analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.