Description

5-(Bromomethyl)Thiophene-2-Carbonitrile is a versatile and high-value heterocyclic building block featuring both a bromomethyl and a nitrile functional group. This compound is critical for the synthesis of complex molecules, enabling efficient carbon-carbon bond formation and further functional group transformations. It is primarily sought after by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing active ingredients and novel polymers.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging the thiophene scaffold for bioactivity.
• Material Science: Serves as a monomer or precursor for conductive polymers, organic semiconductors, and liquid crystal materials.
• Cross-Coupling Reactions: The bromomethyl group is an excellent electrophile for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Nucleophilic Substitution: The reactive bromomethyl site allows for facile substitution with various nucleophiles (amines, thiols, alkoxides) to introduce diverse functionalities.
• Chemical Research: Employed in academic and industrial R&D for exploring new synthetic methodologies and constructing heterocyclic libraries for screening.

Basic Information

Product Name	5-(Bromomethyl)Thiophene-2-Carbonitrile
CAS No.	134135-41-4
Molecular Formula	C6H4BrNS
Molecular Weight	202.07 g/mol
Synonyms	2-Cyano-5-(bromomethyl)thiophene; 5-Bromomethyl-2-cyanothiophene; 2-Thiophenecarbonitrile, 5-(bromomethyl)-; 5-(Bromomethyl)-2-thiophenecarbonitrile; 2-Cyanothiophene-5-methyl bromide; Thiophene-2-carbonitrile, 5-(bromomethyl)-; 5-Bromomethylthiophene-2-carbonitrile
EINECS	Contact for details

Quality Control

Our 5-(Bromomethyl)Thiophene-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.