Description

Ethyl 5-Amino-3-(Trifluoromethyl)-1H-Pyrazole-4-Carboxylate is a high-value, multi-functional pyrazole derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its core value lies in the strategic combination of an amino group and a trifluoromethyl group on the pyrazole scaffold, enabling the synthesis of complex molecules with enhanced biological activity and physicochemical properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in areas like kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and metabolic stability.
• Material Science Precursor: Serves as a starting material for creating specialized heterocyclic compounds used in organic electronics and functional materials.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies and constructing diverse heterocyclic libraries for screening.
• Ligand and Catalyst Development: The amino and ester functionalities make it a useful precursor for synthesizing novel chelating ligands and organocatalysts.

Basic Information

Product Name	Ethyl 5-Amino-3-(Trifluoromethyl)-1H-Pyrazole-4-Carboxylate
CAS No.	133922-58-4
Molecular Formula	C7H8F3N3O2
Molecular Weight	223.16 g/mol
Synonyms	5-Amino-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid ethyl ester; Ethyl 5-amino-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate; 4-Carbethoxy-5-amino-3-trifluoromethylpyrazole; 5-Amino-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid ethyl ester; Ethyl 5-amino-3-trifluoromethylpyrazole-4-carboxylate; ATFEPC; 133922-58-4; 5-Amino-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 5-Amino-3-(Trifluoromethyl)-1H-Pyrazole-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the high standards required for research and cGMP intermediate synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound should be kept away from strong alkalis and fluorides. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.