Description

Chlorotripyrrolidinophosphonium Hexafluorophosphate is a highly reactive organophosphorus reagent, primarily utilized as a powerful coupling agent in peptide synthesis. Its value lies in its efficiency and reliability for forming amide bonds under mild conditions, which is critical for producing high-purity peptides and complex organic molecules. This compound is essential for research institutions, pharmaceutical development labs, and fine chemical manufacturers focused on advanced organic synthesis and bioconjugation.

Application

• Primary reagent for solid-phase and solution-phase peptide synthesis as an efficient coupling agent.
• Facilitates amide bond formation in the synthesis of complex pharmaceuticals and bioactive compounds.
• Used in the preparation of peptidomimetics and other drug candidates in medicinal chemistry research.
• Employed in the synthesis of macrocycles and other constrained molecular structures.
• Key component in bioconjugation strategies for linking peptides to other molecules or surfaces.
• Applied in organic synthesis for the formation of esters and other carboxylic acid derivatives under activating conditions.

Basic Information

Product Name	Chlorotripyrrolidinophosphonium Hexafluorophosphate
CAS No.	133894-48-1
Molecular Formula	C12H24ClF6N3P2
Molecular Weight	445.72 g/mol
Synonyms	PyCloP; Chlorotris(pyrrolidino)phosphonium Hexafluorophosphate; (Pyrrolidino)phosphonium Salt; PyBOP related reagent; Tripyrrolidinophosphonium Chloride Hexafluorophosphate; CTC; Phosphonium, chlorotris(1-pyrrolidinyl)-, hexafluorophosphate(1-); Chlorotris(pyrrolidin-1-yl)phosphonium Hexafluorophosphate
EINECS	Contact for details

Quality Control

Our Chlorotripyrrolidinophosphonium Hexafluorophosphate is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.