Description

1-(tert-Butoxycarbonyl)-2-Indolinecarboxylic Acid is a protected indoline derivative, a crucial building block in modern organic synthesis. Its primary value lies in its role as a versatile intermediate for constructing complex nitrogen-containing heterocycles, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and fine chemical manufacturers engaged in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex indoline-based drug molecules and active pharmaceutical ingredients (APIs).
• Peptidomimetic Synthesis: Serves as a constrained, proline-like amino acid building block for creating novel peptide analogs and protease inhibitors.
• Agrochemical Research: Used in the development of new herbicides and pesticides that leverage the indoline scaffold for biological activity.
• Material Science: Intermediate for synthesizing specialty polymers and organic electronic materials with unique optoelectronic properties.
• Academic & R&D: A fundamental reagent for methodological development in organic chemistry and the exploration of new synthetic pathways.
• Custom Synthesis: Starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	1-(tert-Butoxycarbonyl)-2-Indolinecarboxylic Acid
CAS No.	133851-52-2
Molecular Formula	C14H17NO4
Molecular Weight	263.29 g/mol
Synonyms	2-Indolinecarboxylic acid, 1-[(1,1-dimethylethoxy)carbonyl]-; 1-Boc-2-indolinecarboxylic acid; 1-N-Boc-indoline-2-carboxylic acid; Boc-Indoline-2-COOH; tert-Butyl 2-carboxyindoline-1-carboxylate; (1-Boc-indolin-2-yl)-carboxylic acid; 1-(tert-Butoxycarbonyl)indoline-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-(tert-Butoxycarbonyl)-2-Indolinecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) with detailed batch-specific results are provided to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.