Description

L-Tryptophan-2,3,3-D3 is a stable isotope-labeled analog of the essential amino acid L-Tryptophan, specifically deuterated at the 2, 3, and 3 positions. This precise labeling makes it an invaluable internal standard for quantitative mass spectrometry, ensuring high accuracy and reproducibility in analytical measurements. It is primarily required by research institutions, pharmaceutical companies, and CROs engaged in metabolomics, pharmacokinetic studies, and the development of diagnostic assays where precise quantification of tryptophan and its metabolites is critical.

Application

• Quantitative Mass Spectrometry (MS) & LC-MS/MS: Serves as a critical internal standard for the accurate quantification of endogenous L-Tryptophan and its metabolic pathway derivatives in complex biological matrices like plasma, serum, and tissue homogenates.
• Pharmacokinetic & Bioavailability Studies: Used in drug development to trace and measure the absorption, distribution, metabolism, and excretion (ADME) of tryptophan-containing compounds or drugs affecting tryptophan pathways.
• Clinical Research & Diagnostics: Enables precise measurement of tryptophan and kynurenine pathway metabolites in studies related to neurological disorders, immune function, and metabolic diseases.
• Metabolomics & Biomarker Discovery: Essential for high-fidelity profiling in untargeted and targeted metabolomic studies to identify disease biomarkers related to amino acid metabolism.
• Nutritional Science Research: Facilitates the study of protein metabolism, amino acid requirements, and the impact of diet on tryptophan levels in vivo.
• Stable Isotope Tracer Studies: Acts as a tracer to elucidate metabolic fluxes and pathways in cellular and animal models without interfering with the natural biochemical processes.

Basic Information

Product Name	L-Tryptophan-2,3,3-D3
CAS No.	133519-78-5
Molecular Formula	C11H9D3N2O2
Molecular Weight	207.23 g/mol
Synonyms	(2S)-2-Amino-3-(1H-indol-3-yl)-2,3,3-trideuteropropanoic acid; L-Tryptophan-d3; Tryptophan-2,3,3-d3; (S)-Tryptophan-2,3,3-d3; 3-(3-Indolyl)-2,3,3-trideutero-DL-alanine; DL-Tryptophan-2,3,3-d3; Tryptophan (2,3,3-d3); L-TRP-d3
EINECS	Contact for details

Quality Control

Our L-Tryptophan-2,3,3-D3 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for analytical applications. Each batch undergoes comprehensive testing, including HPLC for chemical purity, NMR and MS for isotopic enrichment verification, and identity confirmation. Certificates of Analysis (COA) detailing the exact isotopic purity (e.g., 98 atom % D), chemical purity, and analytical results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to expected mass profile
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Isotopic Enrichment (Positional)	≥ 95% at 2,3,3-D3
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.