Description

2-Thiophenecarboxylic Acid, 5-(Chlorocarbonyl)-, Methyl Ester (9Ci) is a high-value heterocyclic building block and reactive ester used in advanced organic synthesis. This compound matters for its role as a key intermediate in the production of pharmaceuticals, agrochemicals, and functional materials, enabling the introduction of the thiophene moiety with a versatile, activated carbonyl group. It is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing thiophene heterocycles for therapeutic applications.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the thiophene ring contributes to biological activity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of conductive polymers, organic semiconductors, and advanced polymeric materials.
• Organic Synthesis Reagent: Employed in coupling reactions, such as amide bond formation, and as a versatile electrophile in nucleophilic substitution reactions for constructing complex molecular architectures.
• Ligand and Catalyst Development: Utilized to synthesize novel chelating ligands and organocatalysts for asymmetric synthesis and metal-catalyzed transformations.

Basic Information

Product Name	2-Thiophenecarboxylic Acid, 5-(Chlorocarbonyl)-, Methyl Ester (9Ci)
CAS No.	133380-41-3
Molecular Formula	C7H5ClO3S
Molecular Weight	204.63 g/mol
Synonyms	Methyl 5-(chlorocarbonyl)thiophene-2-carboxylate; 5-(Methoxycarbonyl)thiophene-2-carbonyl chloride; Methyl 5-chloroformyl-2-thiophenecarboxylate; 2-Thiophenecarboxylic acid, 5-(chlorocarbonyl)-, methyl ester; Thiophene-2,5-dicarboxylic acid monomethyl ester chloride; 5-Carbomethoxythiophene-2-carbonyl chloride
EINECS	Contact for details

Quality Control

Our production of 2-Thiophenecarboxylic Acid, 5-(Chlorocarbonyl)-, Methyl Ester (9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.