Description

(R)-2-Methyl-CBS-oxazaborolidine is a highly effective, enantioselective organocatalyst belonging to the Corey-Bakshi-Shibata (CBS) reagent family. Its core value lies in enabling the precise synthesis of chiral alcohols and other valuable intermediates with exceptional enantiomeric excess, which is critical for developing active pharmaceutical ingredients (APIs) and fine chemicals. This catalyst is essential for R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-performance asymmetric transformations.

Application

• Asymmetric Borane Reduction: A premier catalyst for the enantioselective reduction of prochiral ketones to produce chiral secondary alcohols with high optical purity.
• Pharmaceutical Intermediate Synthesis: Critical in the production of chiral building blocks for Active Pharmaceutical Ingredients (APIs), including statins, β-blockers, and antifungal agents.
• Agrochemical Manufacturing: Used to synthesize enantiomerically pure herbicides, fungicides, and plant growth regulators for enhanced efficacy and environmental safety.
• Fine Chemical & Fragrance Production: Enables the creation of chiral flavors, fragrances, and specialty chemicals where stereochemistry defines the organoleptic or functional properties.
• Academic & Industrial R&D: A standard tool in research laboratories for developing new asymmetric synthetic methodologies and exploring novel chiral compounds.
• Material Science: Potential application in the synthesis of chiral polymers and liquid crystals for advanced electronic and optical devices.

Basic Information

Product Name	(R)-2-Methyl-CBS-oxazaborolidine
CAS No.	133261-83-3
Molecular Formula	C18H20BNO
Molecular Weight	277.17 g/mol
Synonyms	(R)-2-Methyl-CBS Catalyst; (R)-2-Methyloxazaborolidine; (R)-Me-CBS; (R)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole; Corey-Bakshi-Shibata Catalyst; (R)-CBS Reagent; (R)-Methyloxazaborolidine Catalyst; (R)-3,3-Diphenyl-1-methyltetrahydro-3H-pyrrolo[1,2-c][1,3,2]oxazaborole
EINECS	Contact for details

Quality Control

Our (R)-2-Methyl-CBS-oxazaborolidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high catalytic performance. Each lot undergoes comprehensive analytical testing, including chiral purity assay and impurity profiling. Certificates of Analysis (COA) detailing specific results for purity, enantiomeric excess, and identity are available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition and maintain catalytic activity. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.