Description

Catharanthine-D3 is a deuterated analog of the monoterpenoid indole alkaloid Catharanthine, a key biosynthetic precursor to the anticancer drugs vinblastine and vincristine. This stable isotope-labeled compound is essential for advanced research in pharmacokinetics, metabolic pathway tracing, and as an internal standard for precise quantitative analysis. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and analytical service providers focused on natural product chemistry and drug development.

Application

• Internal Standard for LC-MS/MS: Provides high-accuracy quantification of Catharanthine and related alkaloids in complex biological matrices.
• Metabolic Pathway Studies: Used as a tracer to investigate the biosynthesis and biotransformation of Vinca alkaloids in plant cell cultures or microbial systems.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical studies.
• Analytical Method Development: Serves as a critical reference material for validating and calibrating sensitive analytical methods like HPLC and mass spectrometry.
• Isotope Dilution Analysis: Improves the accuracy and reliability of quantitative results in pharmaceutical quality control and impurity profiling.
• Biochemical Research: Aids in the study of enzyme mechanisms involved in the biosynthesis of terpenoid indole alkaloids.

Basic Information

Item	Details
Product Name	Catharanthine-D3
CAS No.	133146-02-8
Molecular Formula	C21H21D3N2O2
Molecular Weight	339.44 g/mol
Synonyms	Catharanthine-d3; (19S)-Catharanthine-d3; 3,4-Didehydrocatharanthine-d3; 16-Epi-19S-velbanamine-d3; 19S-Catharanthine-d3; 3',4'-Anhydrovinblastine-d3 (precursor); Stable Isotope Labeled Catharanthine; Deuterated Catharanthine
EINECS	Contact for details

Quality Control

Our Catharanthine-D3 is produced under strict quality management protocols. Each batch is characterized and tested to ensure high chemical and isotopic purity, with specifications typically meeting or exceeding research-grade standards. Comprehensive analysis includes HPLC for chemical purity and MS for isotopic enrichment verification. A detailed Certificate of Analysis (COA), documenting batch-specific results, is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the product at -20°C under inert atmosphere to ensure optimal stability of the deuterated compound.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (MS)	≥ 98 atom % D
Water Content	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.