Description

Ethyl 2-Amino-1-Cyano-5,6,7,8-Tetrahydroindolizine-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused indolizine structure. This compound is of significant commercial importance as a key building block in the synthesis of complex heterocyclic molecules for medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing libraries of compounds in high-throughput screening and structure-activity relationship (SAR) studies.
• Agrochemical Development: Acts as a building block for creating new active ingredients in crop protection and pesticide formulations.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex, high-value specialty chemicals and dyes.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry, reaction mechanisms, and new synthetic methodologies.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis and scale-up projects under GMP or non-GMP conditions.

Basic Information

Product Name	Ethyl 2-Amino-1-Cyano-5,6,7,8-Tetrahydroindolizine-3-Carboxylate
CAS No.	132994-04-8
Molecular Formula	C₁₂H₁₅N₃O₂
Molecular Weight	233.27 g/mol
Synonyms	Ethyl 2-Amino-1-cyano-5,6,7,8-tetrahydroindolizine-3-carboxylate; 2-Amino-1-cyano-5,6,7,8-tetrahydroindolizine-3-carboxylic acid ethyl ester; 1-Cyano-2-amino-5,6,7,8-tetrahydroindolizine-3-carboxylic acid ethyl ester; 5,6,7,8-Tetrahydro-2-amino-1-cyanoindolizine-3-carboxylic acid ethyl ester; Ethyl 2-amino-1-cyano-5,6,7,8-tetrahydroindolizine-3-carboxylate; CAS 132994-04-8; 2-Amino-1-cyanoindolizine-3-carboxylate derivative
EINECS	Contact for details

Quality Control

Our Ethyl 2-Amino-1-Cyano-5,6,7,8-Tetrahydroindolizine-3-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.