Description

5-Trifluoromethoxy-1H-Benzimidazole-2-Amine is a high-purity benzimidazole derivative, a crucial advanced intermediate in modern organic synthesis. Its value lies in its unique trifluoromethoxy-substituted benzimidazole core, which is instrumental in modulating the biological activity and physicochemical properties of target molecules. This compound is primarily sought by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential drug candidates, particularly in antiviral, anticancer, and anti-parasitic research programs.
• Agrochemical Research: Used in the development of new fungicides, herbicides, and insecticides, where the benzimidazole scaffold and fluorine atoms contribute to efficacy and environmental stability.
• Material Science: Serves as a precursor for creating specialized polymers, ligands for catalysis, or organic electronic materials due to its aromatic and heterocyclic structure.
• Biochemical Tool Compound: Utilized in life science research as a probe or inhibitor to study specific enzymatic pathways and biological mechanisms.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom chemical synthesis services catering to the fine chemical and pharmaceutical industries.

Basic Information

Product Name	5-Trifluoromethoxy-1H-Benzimidazole-2-Amine
CAS No.	132877-27-1
Molecular Formula	C8H6F3N3O
Molecular Weight	217.15 g/mol
Synonyms	2-Amino-5-(trifluoromethoxy)-1H-benzimidazole; 5-(Trifluoromethoxy)-1H-benzimidazol-2-amine; 2-Amino-5-trifluoromethoxybenzimidazole; 1H-Benzimidazole-2-amine, 5-(trifluoromethoxy)-; 5-Trifluoromethoxy-2-aminobenzimidazole; 5-Trifluoromethoxybenzimidazol-2-ylamine; Benzimidazole, 2-amino-5-(trifluoromethoxy)-
EINECS	Contact for details

Quality Control

Our 5-Trifluoromethoxy-1H-Benzimidazole-2-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.