Description

(2-Amino-4,5-Dimethyl-3-Thienyl)-[3-(Trifluoromethyl)Phenyl]Methanone is a specialized organic building block featuring a unique thiophene core substituted with an amino group and a trifluoromethylphenyl ketone moiety. This compound is valued for its role as a key intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its structural motifs can impart desirable electronic and biological properties. It is primarily sought by research and development teams, as well as process chemists, in the pharmaceutical, agrochemical, and material science industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders or possessing anti-inflammatory activity.
• Agrochemical Research: Used in the development of new herbicides, fungicides, or insecticides, where the trifluoromethyl group can enhance biological activity and metabolic stability.
• Organic Electronic Materials: Serves as a building block for conjugated polymers or small molecules used in organic light-emitting diodes (OLEDs) or organic photovoltaics (OPVs).
• Ligand Synthesis for Catalysis: The amino and carbonyl functionalities make it a useful starting material for creating novel ligands used in transition metal catalysis.
• Fluorescent Probe Development: Employed in the design of fluorescent dyes or sensors due to the potential for fine-tuning photophysical properties through the thiophene and aromatic systems.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting fundamental research in heterocyclic and fluorine chemistry.

Basic Information

Product Name	(2-Amino-4,5-Dimethyl-3-Thienyl)-[3-(Trifluoromethyl)Phenyl]Methanone
CAS No.	132861-87-1
Molecular Formula	C14H12F3NOS
Molecular Weight	299.31 g/mol
Synonyms	2-Amino-4,5-dimethyl-3-[3-(trifluoromethyl)benzoyl]thiophene; [3-(Trifluoromethyl)phenyl](2-amino-4,5-dimethyl-3-thienyl)methanone; 1-[3-(Trifluoromethyl)phenyl]-2-(2-amino-4,5-dimethyl-3-thienyl)ethanone (tautomer); 3'-Trifluoromethyl-2-amino-4,5-dimethylthienyl phenyl ketone; α-Amino-3'-(trifluoromethyl)desoxybenzoin thiophene analog
EINECS	Contact for details

Quality Control

Our (2-Amino-4,5-Dimethyl-3-Thienyl)-[3-(Trifluoromethyl)Phenyl]Methanone is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.