Description

1H-Indole-2-Carboxylic Acid, 1-[(4-Methylphenyl)Sulfonyl]-, Ethyl Ester is a high-value, synthetically versatile sulfonamide derivative of indole-2-carboxylate. This compound serves as a critical pharmaceutical intermediate and organic building block for constructing complex molecules in medicinal chemistry. It is essential for research and development laboratories, custom synthesis providers, and manufacturers in the pharmaceutical and agrochemical sectors seeking to develop new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and high-throughput screening libraries due to its privileged indole structure.
• Agrochemical Development: Building block for creating new generation pesticides and herbicides with specific biological activity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke organic compounds and APIs (Active Pharmaceutical Ingredients).
• Biochemical Tool Compound: Potential use in developing enzyme inhibitors or receptor modulators for biochemical research.
• Material Science Research: Intermediate for synthesizing specialized organic molecules with potential applications in advanced materials.

Basic Information

Product Name	1H-Indole-2-Carboxylic Acid, 1-[(4-Methylphenyl)Sulfonyl]-, Ethyl Ester
CAS No.	132819-92-2
Molecular Formula	C19H19NO4S
Molecular Weight	357.42 g/mol
Synonyms	Ethyl 1-(p-Toluenesulfonyl)indole-2-carboxylate; Ethyl 1-Tosylindole-2-carboxylate; 1-Tosylindole-2-carboxylic Acid Ethyl Ester; 1-[(4-Methylphenyl)sulfonyl]-1H-indole-2-carboxylic Acid Ethyl Ester; 1H-Indole-2-carboxylic acid, 1-[(4-methylphenyl)sulfonyl]-, ethyl ester; 1-Ts-Indole-2-COOEt; 132819-92-2; Ethyl 1-(4-methylbenzenesulfonyl)-1H-indole-2-carboxylate
EINECS	Contact for details

Quality Control

Our 1H-Indole-2-Carboxylic Acid, 1-[(4-Methylphenyl)Sulfonyl]-, Ethyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of pharmaceutical intermediate supply, supporting our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.