Description

Methyl (2S)-2-(1,3-Dioxoisoindol-2-Yl)-4-Methylpentanoate is a high-purity chiral building block and synthetic intermediate of significant importance in advanced organic synthesis. Its core value lies in providing a protected amino acid derivative, specifically a phthalimide-protected L-leucine methyl ester analog, which is crucial for constructing complex peptide-like structures and active pharmaceutical ingredients (APIs). This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require enantiomerically pure intermediates for the development of new therapeutic agents and fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of peptide-based drugs, protease inhibitors, and other bioactive molecules.
• Agrochemical Synthesis: Used in the research and development of enantiomerically pure pesticides and herbicides.
• Peptidomimetics Research: Serves as a protected amino acid derivative for constructing non-natural peptide analogs in medicinal chemistry.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to introduce chiral centers.
• Chemical Biology Probes: Useful for labeling studies and the development of enzyme inhibitors or receptor ligands.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom API synthesis projects.

Basic Information

Product Name	Methyl (2S)-2-(1,3-Dioxoisoindol-2-Yl)-4-Methylpentanoate
CAS No.	132785-19-4
Molecular Formula	C16H19NO4
Molecular Weight	289.33 g/mol
Synonyms	(S)-Methyl 2-(1,3-dioxoisoindolin-2-yl)-4-methylpentanoate; L-Leucine, N-phthaloyl-, methyl ester; Methyl N-phthaloyl-L-leucinate; (2S)-2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoic acid methyl ester; N-Phthaloyl-L-leucine methyl ester; (S)-2-(1,3-Dioxoisoindolin-2-yl)-4-methylpentanoic acid methyl ester; Phth-Leu-OMe
EINECS	Contact for details

Quality Control

Our Methyl (2S)-2-(1,3-Dioxoisoindol-2-Yl)-4-Methylpentanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for synthetic intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee batch-to-batch consistency and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.