Description

Bromo-Tris-Pyrrolidino-Phosphonium Hexafluorophosphate is a high-purity, advanced phosphonium salt reagent widely used in modern organic synthesis. This compound is valued for its exceptional efficiency as a coupling agent, facilitating the formation of amide bonds and other condensation reactions under mild conditions. It is an essential tool for researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical industries, enabling the production of peptides, active pharmaceutical ingredients (APIs), and complex organic molecules.

Application

• Peptide Synthesis: A key reagent for solid-phase and solution-phase peptide coupling, enabling the efficient formation of amide bonds between amino acids.
• Pharmaceutical Intermediate Manufacturing: Used in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs) requiring high-yield condensation steps.
• Agrochemical Production: Employed in the synthesis of novel herbicides, fungicides, and plant growth regulators that contain amide linkages.
• Bioconjugation: Facilitates the coupling of proteins, antibodies, or other biomolecules with labels, dyes, or drug payloads for diagnostic and therapeutic applications.
• Polymer Chemistry: Acts as a condensing agent in the synthesis of specialized polyamides and other condensation polymers.
• General Organic Synthesis: A versatile reagent for esterification, lactonization, and other dehydration reactions in research and development laboratories.

Basic Information

Product Name	Bromo-Tris-Pyrrolidino-Phosphonium Hexafluorophosphate
CAS No.	132705-51-2
Molecular Formula	C12H24BrF6N3P2
Molecular Weight	466.18 g/mol
Synonyms	PyBroP; Bromo-tris-pyrrolidinophosphonium hexafluorophosphate; (Bromotripyrrolidinophosphonium) hexafluorophosphate; 1-[(1H-Benzotriazol-1-yloxy)(pyrrolidin-1-yl)methylene]pyrrolidinium hexafluorophosphate (common mis-association); BTP; Coupling reagent PyBroP; Phosphonium, bromotris(1-pyrrolidinyl)-, hexafluorophosphate(1-)
EINECS	Contact for details

Quality Control

Our Bromo-Tris-Pyrrolidino-Phosphonium Hexafluorophosphate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain product integrity and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.