Description

α-Methyl-4-(4-Acetyl-2-Thiazolyl)Benzeneacetic Acid is a high-purity, non-steroidal anti-inflammatory drug (NSAID) intermediate with significant synthetic utility. This compound is a critical building block in the pharmaceutical industry, valued for its role in the synthesis of advanced active pharmaceutical ingredients (APIs). It is primarily required by research institutions and manufacturers engaged in the development and production of novel anti-inflammatory and analgesic medications. The consistent quality and reliable supply of this intermediate are paramount for ensuring the integrity of downstream pharmaceutical processes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potent NSAID APIs and related drug candidates.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new therapeutic agents.
• Chemical Synthesis: Serves as a versatile building block for constructing complex heterocyclic molecules containing thiazole and acetic acid moieties.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Process Chemistry: Utilized in scale-up and optimization studies for commercial pharmaceutical manufacturing.

Basic Information

Product Name	α-Methyl-4-(4-Acetyl-2-Thiazolyl)Benzeneacetic Acid
CAS No.	132483-61-5
Molecular Formula	C15H13NO3S
Molecular Weight	287.33 g/mol
Synonyms	2-[4-(4-Acetyl-1,3-thiazol-2-yl)phenyl]propanoic acid; α-Methyl-4-(4-acetyl-2-thiazolyl)benzeneacetic acid; 4-(4-Acetylthiazol-2-yl)-α-methylphenylacetic acid; 2-(4-(4-Acetylthiazol-2-yl)phenyl)propanoic acid; Lornoxicam intermediate; Lornoxicam related compound; Chlortenoxicam intermediate; COX-2 inhibitor intermediate.
EINECS	Contact for details

Quality Control

Our α-Methyl-4-(4-Acetyl-2-Thiazolyl)Benzeneacetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability. Handle and store in accordance with good laboratory practices for chemicals.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.