Description

α-Methyl-4-(4-Ethyl-2-Thiazolyl)Benzeneacetic Acid CAS NO 132483-47-7 is a high-purity, non-steroidal anti-inflammatory drug (NSAID) intermediate of significant commercial importance. This compound is a critical building block in the synthesis of selective COX-2 inhibitors, offering a pathway to advanced pharmaceutical actives with improved therapeutic profiles. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in the production of next-generation analgesic and anti-inflammatory medications.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of selective cyclooxygenase-2 (COX-2) inhibitor drugs, such as certain analogs of celecoxib.
• Anti-inflammatory Drug Development: Serves as a core scaffold for research into novel non-steroidal anti-inflammatory agents with potentially reduced gastrointestinal side effects.
• Fine Chemical Synthesis: Used in multi-step organic synthesis for constructing complex molecules containing the diaryl-substituted thiazole moiety.
• Biochemical Research: Employed in studies investigating COX enzyme inhibition mechanisms and structure-activity relationships (SAR).
• Contract Manufacturing: Supplied to CDMOs for the scale-up and commercial production of patented or generic active pharmaceutical ingredients (APIs).
• Reference Standard: Utilized as an analytical standard for quality control and regulatory submission purposes in API manufacturing.

Basic Information

Product Name	α-Methyl-4-(4-Ethyl-2-Thiazolyl)Benzeneacetic Acid
CAS No.	132483-47-7
Molecular Formula	C₁₅H₁₅NO₂S
Molecular Weight	273.35 g/mol
Synonyms	2-[4-(4-Ethyl-2-thiazolyl)phenyl]propanoic acid; 4-(4-Ethyl-2-thiazolyl)-α-methylbenzeneacetic acid; SC-57666; Celecoxib intermediate; 4-(4-Ethylthiazol-2-yl)-α-methylphenylacetic acid; 2-(4-(4-Ethylthiazol-2-yl)phenyl)propanoic acid; α-Methyl-4-(4-ethyl-2-thiazolyl)benzenacetic acid [alternate spelling]; 132483-47-7
EINECS	Contact for details

Quality Control

Our α-Methyl-4-(4-Ethyl-2-Thiazolyl)Benzeneacetic Acid is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled and stored away from strong light sources. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.