Description

α-Methyl-4-[4-(Trifluoromethyl)-2-Thiazolyl]Benzeneacetic Acid is a high-value, non-steroidal anti-inflammatory drug (NSAID) intermediate characterized by its trifluoromethyl-thiazole moiety. This compound matters for its critical role in the synthesis of advanced pharmaceutical agents, offering a potent scaffold for developing COX-2 inhibitors with improved efficacy and selectivity. Pharmaceutical R&D and manufacturing companies require this precise intermediate to ensure the quality and consistency of final active pharmaceutical ingredients (APIs) targeting pain and inflammation.

Application

• Pharmaceutical Intermediate: Primary building block for the synthesis of novel NSAIDs and COX-2 inhibitors.
• API Synthesis: Used in the final chemical steps to produce active pharmaceutical ingredients for analgesic and anti-inflammatory medications.
• Preclinical & Clinical Research: Serves as a key material in drug discovery programs for inflammatory diseases.
• Chemical Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical laboratories.
• Process Chemistry Development: Utilized in scaling up and optimizing synthetic routes for commercial drug manufacturing.
• Custom Synthesis: Basis for creating derivative compounds with modified pharmacological profiles.

Basic Information

Product Name	α-Methyl-4-[4-(Trifluoromethyl)-2-Thiazolyl]Benzeneacetic Acid
CAS No.	132483-45-5
Molecular Formula	C₁₃H₁₀F₃NO₂S
Molecular Weight	301.28 g/mol
Synonyms	2-(4-(4-(Trifluoromethyl)thiazol-2-yl)phenyl)propanoic acid; α-Methyl-4-(4-(trifluoromethyl)-2-thiazolyl)benzeneacetic acid; 4-[4-(Trifluoromethyl)-1,3-thiazol-2-yl]-α-methylbenzeneacetic acid; 2-[4-[4-(Trifluoromethyl)-1,3-thiazol-2-yl]phenyl]propanoic acid; Valdecoxib Intermediate; COX-2 Inhibitor Intermediate; SC-65872 (related code)
EINECS	Contact for details

Quality Control

Our α-Methyl-4-[4-(Trifluoromethyl)-2-Thiazolyl]Benzeneacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided to guarantee traceability and support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.