Description

n-(4-Aminobenzoyloxy)Succinimide is a specialized active ester intermediate widely used in peptide synthesis and bioconjugation chemistry. This compound matters for its role as a highly effective coupling reagent, facilitating the formation of amide bonds under mild conditions with minimal racemization. Pharmaceutical researchers, peptide chemists, and manufacturers of diagnostic reagents need it for the development of novel APIs, peptide-based drugs, and labeled biomolecules.

Application

• Peptide Synthesis: As a key coupling agent for the efficient formation of peptide bonds in solid-phase and solution-phase synthesis.
• Bioconjugation: For the site-specific labeling of proteins, antibodies, and other biomolecules with fluorescent dyes, drugs, or other functional probes.
• Pharmaceutical Intermediates: In the production of active pharmaceutical ingredients (APIs), particularly for peptide-derived therapeutics.
• Linker Chemistry: Used to create cleavable or stable linkers in prodrug design and antibody-drug conjugates (ADCs).
• Material Science: For the surface functionalization of polymers and nanoparticles to introduce amine-reactive groups.
• Research & Development: A valuable tool in academic and industrial R&D for exploring new synthetic pathways and bioactive compounds.

Basic Information

Product Name	n-(4-Aminobenzoyloxy)Succinimide
CAS No.	132445-64-8
Molecular Formula	C11H10N2O4
Molecular Weight	234.21 g/mol
Synonyms	4-(Succinimidyloxycarbonyl)aniline; N-Succinimidyl 4-aminobenzoate; 4-Aminobenzoic Acid N-Hydroxysuccinimide Ester; 4-Aminobenzoic Acid Succinimidyl Ester; NHS-4-Aminobenzoate; p-Aminobenzoic Acid N-Hydroxysuccinimide Ester; S4AB; 4-(N-Succinimidyloxycarbonyl)aniline
EINECS	Contact for details

Quality Control

Our n-(4-Aminobenzoyloxy)Succinimide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and custom purity grades or specific impurity limits can be discussed to meet your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect reactivity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.