Description

6-Trimethylsilylthio-9-Trimethylsilylpurine is a high-purity, bifunctional silylated purine derivative designed for advanced organic synthesis and pharmaceutical research. This compound serves as a versatile and protected nucleobase intermediate, enabling precise chemical modifications that are critical for developing novel active pharmaceutical ingredients (APIs) and nucleoside analogs. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality building blocks for complex molecular construction.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel purine-based antiviral and anticancer agents.
• Nucleoside Chemistry: Used as a protected precursor for the development of modified nucleosides and nucleotides.
• Agrochemical Research: Intermediate in creating new plant growth regulators or pesticide candidates with purine scaffolds.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) due to the reactive silylthio group.
• Chemical Biology Probes: Utilized in the synthesis of labeled or tagged purine derivatives for biochemical and diagnostic studies.
• Material Science: Potential monomer or modifier in the development of specialty polymers and advanced materials.

Basic Information

Product Name	6-Trimethylsilylthio-9-Trimethylsilylpurine
CAS No.	132151-80-5
Molecular Formula	C11H20N4SSi2
Molecular Weight	272.54 g/mol
Synonyms	9H-Purine, 6-[(trimethylsilyl)thio]-9-(trimethylsilyl)-; 6-(Trimethylsilylthio)-9-(trimethylsilyl)-9H-purine; 6-TMS-thio-9-TMS-purine; Purine, 6-(trimethylsilylthio)-9-(trimethylsilyl)-; 6,9-Bis(trimethylsilyl)thiopurine; 132151-80-5; 6-Trimethylsilylmercapto-9-trimethylsilylpurine
EINECS	Contact for details

Quality Control

Every batch of 6-Trimethylsilylthio-9-Trimethylsilylpurine is manufactured and tested under strict quality management systems to ensure consistency and high purity for research and production use. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.