Description

Thiodiglycolic Acid-D4 is a deuterated isotopologue of thiodiglycolic acid, where four hydrogen atoms are replaced with deuterium. This compound is a critical analytical standard and stable isotope-labeled reagent, essential for ensuring accuracy and reliability in quantitative mass spectrometry. It is primarily required by researchers and quality control laboratories in the pharmaceutical, environmental, and chemical synthesis sectors for use as an internal standard in method development and validation.

Application

• Internal Standard for LC-MS/MS: Serves as a stable isotope-labeled internal standard for the precise quantification of thiodiglycolic acid and related metabolites in complex biological matrices.
• Pharmaceutical Research: Used in drug metabolism and pharmacokinetics (DMPK) studies to track and quantify drug metabolites with high specificity.
• Environmental Analysis: Enables accurate measurement of thiodiglycolic acid as a potential biomarker or pollutant in environmental samples.
• Chemical Synthesis: Acts as a labeled building block for the synthesis of deuterated compounds for mechanistic studies and tracer applications.
• Forensic Toxicology: Supports method development for the detection and confirmation of specific substances in forensic investigations.
• Method Validation: Critical for validating analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA) by providing a non-interfering reference signal.

Basic Information

Product Name	Thiodiglycolic Acid-D4
CAS No.	132090-51-8
Molecular Formula	C4D4H2O4S
Molecular Weight	154.17 g/mol
Synonyms	2,2'-Thiodiacetic Acid-d4; Bis(carboxymethyl) Sulfide-d4; Thiodiacetic Acid-d4; Deuterated Thiodiglycolic Acid; [2H4]-Thiodiglycolic Acid; TDGA-d4; Mercaptodiacetic Acid-d4; (Carboxymethylthio)acetic Acid-d4
EINECS	Contact for details

Quality Control

Our Thiodiglycolic Acid-D4 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for critical analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D-atom %), chemical purity by HPLC, and identity confirmation. We adhere to relevant standards for high-purity reference materials to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-atom %)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.