Description

8-Oxabicyclo[3.2.1]Octane, 6-Ethoxy-4-Methyl-2-(Phenylmethoxy)-, 1R-(2-Exo,4-Exo,6-Endo)- is a high-purity, stereochemically defined bicyclic ether compound. This advanced pharmaceutical intermediate is valued for its precise molecular architecture, which is critical for synthesizing complex active pharmaceutical ingredients (APIs) with specific stereochemical requirements. It is primarily required by R&D laboratories and production facilities in the pharmaceutical and fine chemical sectors for the development and manufacture of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug molecules, particularly those targeting the central nervous system.
• Asymmetric Synthesis: Used in catalytic and stoichiometric asymmetric reactions to introduce specific stereocenters in target molecules.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for API manufacturing under GMP conditions.
• Fine Chemical Synthesis: Used in the production of specialty chemicals, agrochemicals, and fragrances requiring high stereochemical purity.

Basic Information

Product Name	8-Oxabicyclo[3.2.1]Octane, 6-Ethoxy-4-Methyl-2-(Phenylmethoxy)-, 1R-(2-Exo,4-Exo,6-Endo)-
CAS No.	132072-52-7
Molecular Formula	C₁₇H₂₄O₃
Molecular Weight	276.37 g/mol
Synonyms	(1R,2R,4S,6S)-6-Ethoxy-4-methyl-2-(phenylmethoxy)-8-oxabicyclo[3.2.1]octane; 1R-(2-Exo,4-Exo,6-Endo)-6-Ethoxy-4-Methyl-2-(Benzyloxy)-8-Oxabicyclo[3.2.1]Octane; 8-Oxabicyclo[3.2.1]octane, 2-(benzyloxy)-6-ethoxy-4-methyl-, (1R,2R,4S,6S)-rel-; Bicyclic Ether Intermediate 132072-52-7; Benzyloxy-Ethoxy Methyl Oxabicyclooctane
EINECS	Contact for details

Quality Control

Our 8-Oxabicyclo[3.2.1]Octane intermediate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC and NMR, to ensure high chemical and stereochemical purity suitable for pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with ICH Q7 and cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere to maintain stability and prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.