Description

3-Morpholino-1H-Indazol-5-Amine is a high-purity, advanced pharmaceutical intermediate characterized by its unique indazole-morpholine hybrid structure. This compound is of significant commercial value for its role as a critical building block in the synthesis of novel, small-molecule therapeutics. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in drug discovery programs, particularly those targeting kinase inhibition and other key biological pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of investigational new drugs (INDs) and active pharmaceutical ingredients (APIs), especially for oncology and anti-inflammatory applications.
• Kinase Inhibitor Development: Serves as a core scaffold for designing and optimizing potent and selective kinase inhibitors due to its privileged heterocyclic structure.
• Biochemical Research: Used as a standard or reagent in high-throughput screening (HTS) and structure-activity relationship (SAR) studies within medicinal chemistry.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of complex molecules for clinical trials.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and chemical biology.

Basic Information

Product Name	3-Morpholino-1H-Indazol-5-Amine
CAS No.	131875-38-2
Molecular Formula	C11H14N4O
Molecular Weight	218.26 g/mol
Synonyms	5-Amino-3-morpholino-1H-indazole; 1H-Indazol-5-amine, 3-morpholino-; 3-Morpholin-4-yl-1H-indazol-5-ylamine; 3-Morpholino-5-aminoindazole; 131875-38-2; 3-Morpholinoindazol-5-amine; 5-Amino-3-(morpholin-4-yl)-1H-indazole
EINECS	Contact for details

Quality Control

Our 3-Morpholino-1H-Indazol-5-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee traceability, consistency, and compliance with your project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.