Description

1-Methylpyrrolidine-2,2,3,3,4,4,5,5-D8 is a deuterated analog of 1-methylpyrrolidine, where eight hydrogen atoms are replaced by deuterium, a stable hydrogen isotope. This high isotopic purity is critical for applications requiring non-radioactive isotopic labeling, such as internal standards in mass spectrometry to ensure precise quantitative analysis. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry sectors for advanced spectroscopic studies and metabolic research.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a critical quantitative reference standard in LC-MS and GC-MS analysis for pharmaceuticals and metabolites.
• NMR Solvent & Reagent: Used as a deuterated solvent or reagent in Nuclear Magnetic Resonance (NMR) spectroscopy to study molecular structure and dynamics without proton interference.
• Pharmaceutical Research & Development: Employed in drug discovery and development for tracing metabolic pathways and conducting pharmacokinetic (PK) studies.
• Metabolomics and Biomarker Discovery: Facilitates accurate identification and quantification of small molecules in complex biological samples.
• Chemical Synthesis Intermediate: Acts as a building block for synthesizing more complex deuterated compounds used in various research fields.
• Agrochemical Research: Used in the development and analysis of deuterated pesticides or plant growth regulators.

Basic Information

Product Name	1-Methylpyrrolidine-2,2,3,3,4,4,5,5-D8
CAS No.	131857-29-9
Molecular Formula	C5D8N
Molecular Weight	90.18 g/mol
Synonyms	N-Methylpyrrolidine-d8; Perdeuterated N-Methylpyrrolidine; 1-Methylpyrrolidine-d8; N-Methyltetrahydropyrrole-d8; Pyrrolidine, 1-methyl-2,2,3,3,4,4,5,5-d8-; Tetrahydro-1-methylpyrrole-d8; Deuterated 1-Methylpyrrolidine; NMP-d8
EINECS	Contact for details

Quality Control

Our deuterated chemicals are produced under strict quality control to ensure high isotopic and chemical purity. Each batch is analyzed using advanced techniques including NMR, GC-MS, and HPLC to verify conformity. Certificates of Analysis (COA) detailing isotopic enrichment (typically >98 atom % D), chemical purity, and specific tests are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.