Description

(S,S)-4,4′-Diisopropyl-4,5,4′,5′-Tetrahydro[2.2]Bioxazolyl CAS NO 131833-89-1 is a high-purity, chiral bioxazoline ligand, a critical component in asymmetric synthesis. Its value lies in its ability to act as a highly effective and selective catalyst or ligand in metal-catalyzed reactions, enabling the production of enantiomerically pure compounds. This product is essential for research and development laboratories, as well as production facilities in the pharmaceutical, agrochemical, and fine chemical industries, where precise stereochemical control is paramount for creating active ingredients and advanced intermediates.

Application

• Asymmetric Catalysis: As a privileged chiral ligand for transition metals like copper, nickel, and palladium in enantioselective transformations.
• Pharmaceutical Intermediates: Synthesis of chiral active pharmaceutical ingredients (APIs) requiring high enantiomeric excess (ee).
• Agrochemical Synthesis: Production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Manufacturing: Key reagent in the synthesis of complex, high-value specialty chemicals and flavors/fragrances.
• Academic & Industrial R&D: A fundamental tool for developing new catalytic methodologies and exploring novel reaction pathways in organic chemistry.
• Cross-Coupling Reactions: Facilitating enantioselective C-C, C-N, and C-O bond-forming reactions.
• Cyclopropanation & Aziridination: As a ligand in metal-catalyzed enantioselective cyclopropanation and aziridination reactions.

Basic Information

Product Name	(S,S)-4,4′-Diisopropyl-4,5,4′,5′-Tetrahydro[2.2]Bioxazolyl
CAS No.	131833-89-1
Molecular Formula	C14H26N2O2
Molecular Weight	254.37 g/mol
Synonyms	(4S,4'S)-4,4'-Diisopropyl-4,5,4',5'-tetrahydro-2,2'-bioxazole; (S,S)-4,4'-Diisopropyl-2,2'-bi-2-oxazoline; (S,S)-i-Pr-Box; (S,S)-DIP-BOX; (S,S)-Diisopropyl-BOX; (S,S)-2,2'-Isopropylidenebis(4-isopropyl-4,5-dihydrooxazole); Chiral Bioxazoline Ligand; BOX Ligand
EINECS	Contact for details

Quality Control

Our (S,S)-4,4′-Diisopropyl-4,5,4′,5′-Tetrahydro[2.2]Bioxazolyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, chiral integrity, and batch-to-batch consistency. Standard quality parameters include assay by HPLC, determination of enantiomeric excess (ee), and identification by spectroscopic methods. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.