Description

n-[2-(4-Hydroxyphenyl)Ethyl]Acetamide-D3 is a deuterated isotopologue of the phenolic compound N-[2-(4-Hydroxyphenyl)ethyl]acetamide, where three hydrogen atoms are replaced by deuterium, a stable isotope of hydrogen. This deuteration is critical for enhancing analytical precision in mass spectrometry and NMR studies, serving as a stable internal standard for accurate quantification. It is primarily utilized by pharmaceutical and analytical chemistry laboratories engaged in pharmacokinetic research, metabolic profiling, and quality control of related active pharmaceutical ingredients.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference standard in quantitative bioanalysis for drug metabolism and pharmacokinetics (DMPK) studies.
• Metabolite Tracing: Used in stable isotope labeling experiments to trace metabolic pathways and identify drug metabolites.
• Pharmaceutical Impurity Profiling: Acts as a deuterated marker in the development and validation of analytical methods for impurity identification.
• NMR Spectroscopy: Provides a non-radioactive isotopic label for structural elucidation and mechanistic studies in organic and medicinal chemistry.
• Reference Material for Certified Standards: Used by manufacturers to produce certified reference materials (CRMs) with defined isotopic purity.

Basic Information

Product Name	n-[2-(4-Hydroxyphenyl)Ethyl]Acetamide-D3
CAS No.	131815-58-2
Molecular Formula	C10H10D3NO2
Molecular Weight	181.24 g/mol (approx.)
Synonyms	N-[2-(4-Hydroxyphenyl)ethyl]acetamide-d3; 4-Hydroxyphenethylacetamide-d3; N-Acetyltyramine-d3; N-(2-(4-Hydroxyphenyl)ethyl)acetamide-d3; Acetamide, N-[2-(4-hydroxyphenyl)ethyl]-d3; Tyramine N-acetate-d3; Deuterated N-Acetyltyramine; [D3]-N-Acetyltyramine
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality control to ensure high isotopic and chemical purity, essential for reliable analytical results. Each batch is characterized by advanced techniques including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) are provided, detailing parameters such as chemical purity, isotopic enrichment (D-content), and specific tests for identity and impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.