Description

8-(Chloromethyl)-6-Fluoro-4H-1,3-Benzodioxine CAS NO 131728-94-4 is a high-purity fluorinated benzodioxine derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in its unique molecular scaffold, which combines a reactive chloromethyl group with a fluorine substituent, enabling precise structural modifications for complex molecule construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides, leveraging the fluorine atom for enhanced bioactivity and stability.
• Material Science Research: Serves as a precursor for developing specialty polymers and advanced organic electronic materials with tailored properties.
• Ligand and Catalyst Development: Employed in the creation of complex chelating ligands and organocatalysts for asymmetric synthesis.
• Fluorine Chemistry Studies: A valuable substrate for investigating new fluorination reactions and studying structure-activity relationships (SAR).
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke molecules for client projects.

Basic Information

Product Name	8-(Chloromethyl)-6-Fluoro-4H-1,3-Benzodioxine
CAS No.	131728-94-4
Molecular Formula	C9H6ClFO2
Molecular Weight	200.59 g/mol
Synonyms	6-Fluoro-8-(chloromethyl)-4H-1,3-benzodioxine; 8-Chloromethyl-6-fluoro-4H-benzo[d][1,3]dioxine; 4H-1,3-Benzodioxine, 8-(chloromethyl)-6-fluoro-; 6-Fluoro-8-chloromethyl-1,3-benzodioxin; 131728-94-4; 8-(Chloromethyl)-6-fluoro-1,3-benzodioxole; Fluorinated benzodioxine chloromethyl derivative
EINECS	Contact for details

Quality Control

Every batch of 8-(Chloromethyl)-6-Fluoro-4H-1,3-Benzodioxine is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the stringent requirements of our global clientele. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.