Description

n-Acetyl-D3-L-Cysteine is a stable, deuterium-labeled derivative of the amino acid L-cysteine, specifically designed for research and analytical applications. This compound matters as a critical internal standard and tracer in mass spectrometry-based studies, enabling precise quantification and metabolic pathway analysis. It is primarily needed by pharmaceutical R&D teams, clinical research organizations, and analytical laboratories working in drug metabolism, pharmacokinetics, and biomarker discovery.

Application

• Mass Spectrometry Internal Standard: Used as a stable isotope-labeled reference for the accurate quantification of endogenous L-cysteine, glutathione, and related metabolites in biological samples via LC-MS/MS and GC-MS.
• Drug Metabolism & Pharmacokinetics (DMPK): Serves as a tracer to study the absorption, distribution, metabolism, and excretion (ADME) of cysteine-containing drugs and nutraceuticals.
• Biomarker Research: Employed in the development and validation of assays for oxidative stress markers, where cysteine and its derivatives play a key role.
• Proteomics & Biochemical Research: Acts as a tool compound for investigating protein structure, disulfide bond formation, and redox biology mechanisms.
• Pharmaceutical Reference Standard: Provides a certified reference material for quality control and method validation in pharmaceutical analysis.
• Nutritional Science Studies: Used in metabolic tracer studies to understand the utilization and turnover of sulfur-containing amino acids in nutritional supplements.

Basic Information

Product Name	n-Acetyl-D3-L-Cysteine
CAS No.	131685-11-5
Molecular Formula	C5H6D3NO3S
Molecular Weight	165.21 g/mol
Synonyms	N-Acetyl-L-cysteine-d3; (R)-2-Acetamido-3-mercaptopropionic-3,3,3-d3 acid; Acetylcysteine-d3; NAC-d3; L-Cysteine, N-acetyl-, (3,3,3-d3)-; 3,3,3-Trideutero-N-acetyl-L-cysteine; N-Acetyl-3,3,3-d3-L-cysteine; Deuterated N-Acetylcysteine
EINECS	Contact for details

Quality Control

Our n-Acetyl-D3-L-Cysteine is manufactured under strict quality systems to ensure high chemical purity and isotopic enrichment. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and analytical results from techniques such as NMR, HPLC, and MS. We are committed to supplying materials suitable for demanding analytical applications, with specifications that can meet research and GLP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Chemical Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.