Description

n-Blocked-5'-o-Dmt-2'-o-Fpmp Ced Uridine Phosphoramidite is a highly specialized, protected nucleoside phosphoramidite monomer, a critical building block in solid-phase oligonucleotide synthesis. Its value lies in enabling the precise and automated assembly of complex RNA sequences, where the 2'-hydroxyl protecting group is crucial for controlling regioselectivity. This compound is essential for researchers and manufacturers in the fields of therapeutic oligonucleotide development, antisense technology, and diagnostic probe synthesis.

Application

• Synthesis of therapeutic RNA oligonucleotides, including siRNA and antisense RNA for gene silencing applications.
• Manufacturing of research-grade RNA probes and primers for molecular biology and diagnostics.
• Production of modified RNA sequences for structural studies, aptamer development, and bio-conjugation.
• Automated solid-phase oligonucleotide synthesis on DNA/RNA synthesizers for high-throughput production.
• Development of oligonucleotide libraries for drug discovery and high-content screening platforms.

Basic Information

Product Name	n-Blocked-5'-o-Dmt-2'-o-Fpmp Ced Uridine Phosphoramidite
CAS No.	131501-59-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-O-[(R)-1-(2-Fluorophenyl)-4-methoxypiperidin-4-yl]uridine 3'-[(2-Cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 2'-O-FPMP Protected Uridine Phosphoramidite; 2'-O-(1-(2-Fluorophenyl)-4-methoxypiperidin-4-yl) Uridine Phosphoramidite; DMT-2'-O-FPMP-U-CE Phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; FPMP-protected U Phosphoramidite.
EINECS	Contact for details

Quality Control

Our n-Blocked-5'-o-Dmt-2'-o-Fpmp Ced Uridine Phosphoramidite is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive oligonucleotide synthesis. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis, ³¹P and ¹H NMR spectroscopy for structural confirmation, and moisture content determination. Certificates of Analysis (COA) with full specification data are provided to support your GMP or research-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will lead to decomposition and reduced coupling efficiency.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (³¹P NMR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.