Description

Arecoline-D5 Hydrobromide Salt is a deuterated internal standard of the alkaloid arecoline, specifically designed for analytical and research applications. This high-purity compound is essential for ensuring accurate quantification and method validation in mass spectrometry-based analyses. It is primarily utilized by analytical laboratories, pharmaceutical researchers, and forensic toxicologists working on pharmacokinetic studies, metabolic profiling, and quality control of related substances.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the precise quantification of arecoline and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic and Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Forensic and Clinical Toxicology: Supports the development and validation of sensitive assays for detecting arecoline exposure in forensic investigations or clinical settings.
• Metabolite Identification and Profiling: Aids in the identification and structural elucidation of arecoline metabolites using high-resolution mass spectrometry.
• Method Development and Validation: Serves as a critical reference material for developing robust, reproducible, and GLP-compliant analytical methods.
• Quality Control in Pharmaceutical Research: Used in the quality assurance and stability testing of pharmaceutical formulations containing arecoline or related compounds.

Basic Information

Product Name	Arecoline-D5 Hydrobromide Salt
CAS No.	131448-17-4
Molecular Formula	C8H8D5NO2·HBr
Molecular Weight	260.17 g/mol
Synonyms	Arecoline-d5 HBr; 1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxylic acid methyl ester-d5 hydrobromide; Methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate-d5 hydrobromide; N-Methyltetrahydronicotinic acid methyl ester-d5 hydrobromide; Arecoline (methyl-d3, 3,4,5,6-d4) hydrobromide; Deuterated Arecoline Hydrobromide; Arecoline Internal Standard
EINECS	Contact for details

Quality Control

Our Arecoline-D5 Hydrobromide Salt is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (D-enrichment), chemical purity (HPLC), and identification (NMR, MS). We support research and development requiring compliance with GMP/GLP principles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.