Description

(Hydroxyethoxyethoxy)-T-Butyl Dimethylsilane is a specialized organosilicon compound featuring a hydrophilic oligo(ethylene glycol) chain and a robust tert-butyldimethylsilyl (TBDMS) protecting group. This unique structure makes it a valuable intermediate for introducing protected polyether functionalities in advanced organic synthesis. It is particularly essential for researchers and manufacturers in the pharmaceutical and advanced materials sectors who require precise molecular building blocks. The compound is used to create complex molecules where controlled solubility and selective deprotection are critical.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring PEGylated side chains or protected alcohol functionalities.
• Polymer & Material Science: Monomer or modifier for creating specialty silicones and polymers with tailored surface properties, hydrophilicity, and biocompatibility.
• Surface Modification: Used to derivatize surfaces (e.g., silica, glass) to create hydrophilic, non-fouling coatings for biomedical devices and sensors.
• Linker Chemistry: Serves as a versatile spacer or linker in bioconjugation and the development of drug delivery systems such as antibody-drug conjugates (ADCs).
• Organic Synthesis Reagent: Employed as a protecting group reagent for alcohols in multi-step synthetic routes, offering stability under a wide range of conditions.
• Cross-coupling Reactions: Can be utilized in palladium-catalyzed reactions to introduce functionalized silane groups into complex molecular architectures.

Basic Information

Product Name	(Hydroxyethoxyethoxy)-T-Butyl Dimethylsilane
CAS No.	131326-39-1
Molecular Formula	C₁₂H₂₈O₃Si
Molecular Weight	248.44 g/mol
Synonyms	2-[2-(2-Hydroxyethoxy)ethoxy]ethyl tert-butyldimethylsilyl ether; 2-[2-(2-[(tert-Butyldimethylsilyl)oxy]ethoxy)ethoxy]ethanol; TBDMS-PEG3-OH; tert-Butyl[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]dimethylsilane; (2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy)(tert-butyl)dimethylsilane; 3,6,9-Trioxa-2-siladodecan-12-ol, 2,2-dimethyl-10-(1,1-dimethylethyl)-; PEG3-TBDMS; Hydroxy-PEG3-TBDMS
EINECS	Contact for details

Quality Control

Our (Hydroxyethoxyethoxy)-T-Butyl Dimethylsilane is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chromatography (HPLC, GC) and spectroscopic methods (NMR, IR), to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.