Description

1,2-Benzenediol, 4-Fluoro-5-[(1R)-1-Hydroxy-2-(Methylamino)Ethyl]- (9Ci) CAS NO 131233-81-3 is a specialized chiral catechol derivative, distinguished by its fluorinated and amino alcohol substituents. This compound is a critical synthetic intermediate for the development of advanced pharmaceutical agents, particularly in the areas of adrenergic receptor modulation and central nervous system (CNS) therapeutics. It is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical and fine chemical industries seeking to build complex, bioactive molecules with high stereochemical purity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated catecholamine analogs and β-adrenergic receptor ligands.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the research and production of potential drugs targeting cardiovascular and neurological disorders.
• Asymmetric Synthesis: Serves as a chiral precursor or auxiliary in stereoselective chemical reactions due to its defined (R)-configuration.
• Biochemical Research: Valuable tool compound for studying enzyme mechanisms, receptor binding, and metabolic pathways involving catechol structures.
• Fine Chemical Production: Intermediate for creating complex fluorinated organic compounds with specific biological activity.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	1,2-Benzenediol, 4-Fluoro-5-[(1R)-1-Hydroxy-2-(Methylamino)Ethyl]- (9Ci)
CAS No.	131233-81-3
Molecular Formula	C9H12FNO3
Molecular Weight	201.20 g/mol
Synonyms	4-Fluoro-5-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol; (R)-4-Fluoro-5-(1-hydroxy-2-(methylamino)ethyl)benzene-1,2-diol; (R)-4-Fluoro-5-(1-hydroxy-2-(methylamino)ethyl)catechol; A fluorinated chiral amino-catechol derivative; 4-Fluoro-5-[(R)-1-hydroxy-2-(methylamino)ethyl]-1,2-benzenediol; 131233-81-3; 9CI Index Name Compound
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high chemical purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, chiral analysis, and NMR spectroscopy. A Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with each shipment. We support development and cGMP manufacturing needs with appropriate documentation.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation and light, prolonged exposure to air or light should be avoided.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (R)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.