Description

(S)-Alpha,α-Bis(4-Methylphenyl)-2-Pyrrolidinemethanol CAS NO 131180-52-4 is a high-purity chiral compound belonging to the pyrrolidinemethanol class, valued for its role as a key intermediate in asymmetric synthesis. Its primary commercial significance lies in its application as a precursor or ligand in the production of advanced pharmaceutical active ingredients and fine chemicals. This product is essential for research and development laboratories, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to leverage its stereochemical properties for creating enantiomerically pure products.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of enantiomerically pure drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Catalyst Ligand Precursor: Used in the development and preparation of chiral catalysts for asymmetric hydrogenation and other stereoselective transformations.
• Agrochemical Synthesis: Serves as an intermediate in the production of chiral pesticides and herbicides, where specific stereochemistry is required for biological activity.
• Academic & Industrial R&D: A valuable reagent for method development and exploration of new synthetic pathways in organic and medicinal chemistry.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances that require high stereochemical purity.

Basic Information

Product Name	(S)-Alpha,α-Bis(4-Methylphenyl)-2-Pyrrolidinemethanol
CAS No.	131180-52-4
Molecular Formula	C20H25NO
Molecular Weight	295.42 g/mol
Synonyms	(S)-α,α-Bis(4-methylphenyl)-2-pyrrolidinemethanol; (S)-2-Pyrrolidinemethanol, α,α-bis(4-methylphenyl)-; (S)-α,α-Di-p-tolyl-2-pyrrolidinemethanol; (S)-DTBM-SEGPHOS precursor; (S)-Bis(4-methylphenyl)(pyrrolidin-2-yl)methanol; (S)-H8-BINAP derivative intermediate; Ligand precursor L*
EINECS	Contact for details

Quality Control

Our (S)-Alpha,α-Bis(4-Methylphenyl)-2-Pyrrolidinemethanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical and advanced synthetic applications. Certificates of Analysis (COA) documenting identity, purity, and enantiomeric excess are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.