Description

1,4-Benzene-2,3,5,6-D4-Dicarboxaldehyde is a deuterated derivative of terephthalaldehyde, where four hydrogen atoms are replaced with deuterium, a stable hydrogen isotope. This deuteration provides a valuable tool for spectroscopic studies and mechanistic investigations, offering distinct advantages in research requiring isotopic labeling. It is primarily utilized by researchers and manufacturers in the fields of pharmaceutical development, advanced material science, and analytical chemistry for applications such as NMR spectroscopy, mass spectrometry, and the synthesis of labeled compounds.

Application

• NMR Spectroscopy Internal Standard: Serves as a precise internal reference or shift reagent in nuclear magnetic resonance (NMR) studies due to its distinct deuterium signature.
• Isotopic Labeling in Pharmaceutical Research: Used as a building block for synthesizing deuterium-labeled drug candidates to study pharmacokinetics, metabolism, and bioavailability (Drug Metabolism and Pharmacokinetics - DMPK).
• Mass Spectrometry Tracer: Acts as a stable isotopic tracer in mass spectrometry for quantitative analysis and metabolic pathway elucidation.
• Advanced Material Synthesis: Employed in the research and development of specialized polymers, organic frameworks (e.g., MOFs, COFs), and liquid crystals where isotopic purity can influence material properties.
• Mechanistic Reaction Studies: Facilitates the investigation of chemical reaction mechanisms by tracing the fate of specific atoms through isotopic labeling.
• Analytical Reference Standard: Provides a high-purity, characterized reference material for quality control and method development in analytical laboratories.

Basic Information

Product Name	1,4-Benzene-2,3,5,6-D4-Dicarboxaldehyde
CAS No.	131170-44-0
Molecular Formula	C8D4H2O2
Molecular Weight	140.16 g/mol
Synonyms	Terephthalaldehyde-d4; Benzene-1,4-dicarboxaldehyde-2,3,5,6-d4; 1,4-Benzenedicarboxaldehyde-2,3,5,6-d4; p-Phthalaldehyde-d4; Deutrated Terephthalaldehyde; D4-Terephthalaldehyde; Isotopically Labeled Terephthaldehyde; [D4]-TPA
EINECS	Contact for details

Quality Control

Our deuterated chemicals are produced and tested under stringent quality protocols to ensure high isotopic and chemical purity. Each batch of 1,4-Benzene-2,3,5,6-D4-Dicarboxaldehyde is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (D-atom %), chemical purity (by HPLC/GC), and identification. We support research and industrial standards, and specifications can be aligned with customer requirements for specific applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to moisture during use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-atom %)	≥ 98.0% (by 1H NMR or MS)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.