Description

Benzenethiol, 2-Amino-4,5-Difluoro- (9Ci) is a fluorinated aromatic thiol building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both an amino and a thiol group on a difluorobenzene ring, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the fluorine atoms enhance biological activity and metabolic stability.
• Ligand and Catalyst Precursor: Serves as a precursor for chelating ligands in transition metal catalysis and as a modifier for metal surfaces.
• Material Science Research: Employed in the creation of advanced polymers, liquid crystals, and organic electronic materials due to its unique electronic properties.
• Chemical Biology Probes: Useful for bioconjugation and labeling applications, leveraging the reactivity of the thiol group.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	Benzenethiol, 2-Amino-4,5-Difluoro- (9Ci)
CAS No.	131105-93-6
Molecular Formula	C6H5F2NS
Molecular Weight	161.17 g/mol
Synonyms	2-Amino-4,5-difluorobenzenethiol; 4,5-Difluoro-2-aminobenzenethiol; 2-Amino-4,5-difluorothiophenol; 1-Amino-2-mercapto-4,5-difluorobenzene; 2-Mercapto-4,5-difluoroaniline; 4,5-Difluoro-2-aminothiophenol; 2-Amino-4,5-difluorophenyl mercaptan
EINECS	Contact for details

Quality Control

Our Benzenethiol, 2-Amino-4,5-Difluoro- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation, the container should be kept sealed under positive pressure of inert gas after opening.

Specification

Item	Specification
Appearance	White to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.