Description

Fmoc-Val-Osu CAS NO 130878-68-1 is a high-purity, activated ester derivative of the amino acid valine, protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the efficient and controlled incorporation of valine residues into peptide chains. It is an essential reagent for pharmaceutical R&D, biotechnology, and academic research focused on developing novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the automated, stepwise synthesis of custom peptides using Fmoc-chemistry protocols.
• Pharmaceutical Research: Used in the development and production of peptide drugs, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation: Facilitates the site-specific labeling of peptides with probes, tags, or other molecules for diagnostic and imaging applications.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive peptide leads.
• Academic & Biochemical Research: Essential for studying protein structure-function relationships, enzyme substrates, and receptor-ligand interactions.
• Antibody-Drug Conjugate (ADC) Development: Used in the synthesis of peptide linkers that connect cytotoxic drugs to antibodies.

Basic Information

Product Name	Fmoc-Val-Osu
CAS No.	130878-68-1
Molecular Formula	C21H20N2O6
Molecular Weight	396.40 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valine N-hydroxysuccinimide ester; Fmoc-L-valine-OSu; Fmoc-Val-OSu; Fmoc-Valine-OSu ester; N-Fmoc-L-valine succinimidyl ester; N-α-Fmoc-L-valine N-succinimidyl ester; (9-Fluorenylmethyloxycarbonyl)-L-valine N-hydroxysuccinimide ester; Fmoc-Val-ONSu
EINECS	Contact for details

Quality Control

Our Fmoc-Val-Osu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity, essential for sensitive peptide synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -15°C under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation	[α]²⁰D: -15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.