Description

1-(9-Mercaptononyl)-3,6,9-Trioxaundecan-11-Ol is a specialized bifunctional organic compound featuring both a terminal thiol (mercapto) group and a terminal hydroxyl group, linked by a polyether spacer. This unique structure makes it a valuable heterobifunctional linker and building block for surface modification, polymer synthesis, and bioconjugation. It is particularly sought after by researchers and manufacturers in the life sciences and advanced materials sectors. The compound is supplied with the CAS number 130727-41-2.

Application

• Bioconjugation and Protein/Peptide Modification: The thiol group selectively reacts with maleimides or haloacetyl groups, while the hydroxyl group can be further activated or used for coupling, enabling the creation of custom biomolecule conjugates.
• Surface Functionalization and Self-Assembled Monolayers (SAMs): Used to create hydrophilic, polyether-terminated surfaces on gold or other metals via the thiol group, imparting specific chemical and physical properties for biosensor and diagnostic device development.
• Polymer Chemistry and Crosslinking Agent: Serves as a chain extender or crosslinker in the synthesis of polyurethanes, polyesters, and other polymers, where the different reactive groups allow for controlled polymerization architectures.
• Nanoparticle and Quantum Dot Capping Ligand: Provides stable, water-dispersible coatings on nanoparticles through thiol-metal bonding, with the polyether and hydroxyl groups enhancing biocompatibility and solubility.
• Hydrogel Formation: Acts as a component in the formation of hydrogels through thiol-ene or other click chemistry reactions, useful for tissue engineering and drug delivery scaffolds.
• Intermediate for Specialty Surfactants and Lubricants: The combination of a hydrophobic alkyl chain and hydrophilic polyether/hydroxyl tail makes it a precursor for synthesizing novel non-ionic surfactants and functional lubricant additives.

Basic Information

Product Name	1-(9-Mercaptononyl)-3,6,9-Trioxaundecan-11-Ol
CAS No.	130727-41-2
Molecular Formula	C₁₈H₃₈O₄S
Molecular Weight	350.56 g/mol
Synonyms	11-Hydroxy-3,6,9-trioxa-1-thiahenicosan-21-ol; 9-Mercaptononyl PEG 3 alcohol; HS-C9-PEG3-OH; α-Mercapto-ω-hydroxy tetraethylene glycol undecane; Thiol-PEG3-alcohol (C9); 1-Mercapto-11-hydroxyl-3,6,9-trioxaundecane; Heterobifunctional PEG, SH-PEG3-OH (C9); 21-Mercapto-3,6,9-trioxahenicosan-1-ol
EINECS	Contact for details

Quality Control

Our production of 1-(9-Mercaptononyl)-3,6,9-Trioxaundecan-11-Ol adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and industrial applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and titration to confirm identity, assay, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and moisture absorption. For long-term storage, desiccants are recommended. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Thiol Content (Titration)	≥ 95.0% of theoretical
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.