Description

L-Cysteine (3,3-D2) is a deuterium-labeled derivative of the essential amino acid L-Cysteine, specifically labeled at the 3,3-positions. This stable isotope-labeled compound is a critical tool for advanced research and analytical applications, offering a non-radioactive tracer with distinct mass spectral properties. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for applications such as metabolic pathway studies, protein structure elucidation, and as an internal standard for quantitative mass spectrometry.

Application

• Internal Standard for Quantitative Analysis: Used in LC-MS/MS and GC-MS for the accurate quantification of endogenous L-Cysteine and related metabolites in biological samples.
• Metabolic Pathway Tracing: Serves as a stable isotope tracer in pharmacokinetic, pharmacodynamic, and metabolic flux studies to track the incorporation and fate of cysteine.
• Protein and Peptide Research: Employed in NMR spectroscopy and mass spectrometry for investigating protein structure, dynamics, and folding mechanisms.
• Deuterated Reference Material: Acts as a certified reference standard for method development, validation, and quality control in analytical laboratories.
• Nutritional Research: Used in studies examining sulfur amino acid metabolism, glutathione synthesis, and redox biology.
• Pharmaceutical Development: Facilitates drug metabolism and disposition (DMPK) studies for cysteine-containing drug candidates.

Basic Information

Product Name	L-Cysteine (3,3-D2)
CAS No.	130633-02-2
Molecular Formula	C3H5D2NO2S
Molecular Weight	123.17 g/mol (for monoisotopic mass)
Synonyms	(2R)-2-Amino-3,3-dideuterio-3-sulfanylpropanoic acid; L-Cysteine-d2; L-Cysteine-3,3-d2; (R)-2-Amino-3,3-d2-3-mercaptopropionic acid; Cysteine-3,3-d2; Deuterated L-Cysteine; Stable Isotope Labeled L-Cysteine
EINECS	Contact for details

Quality Control

Our L-Cysteine (3,3-D2) is produced under strict quality management systems to ensure the highest standards of isotopic and chemical purity. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm identity, chemical purity, isotopic enrichment, and chiral purity. A comprehensive Certificate of Analysis (COA) detailing all specifications, including isotopic purity (atom % D), is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 99.0% at 3,3-positions
Optical Rotation	Specific range provided on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.