Description

(3R)-3-Amino-4,5-Dihydrothiophene-2(3H)-One CAS NO 130548-06-0 is a high-purity chiral building block featuring a saturated thiophene backbone with an amino functional group. This compound is a critical intermediate in the synthesis of complex pharmaceutical molecules, particularly those targeting central nervous system disorders. It is essential for research and development chemists in the pharmaceutical and agrochemical industries who require enantiomerically pure intermediates for advanced drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially in neurological and psychiatric drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where specific stereochemistry is required for biological activity.
• Asymmetric Catalysis Research: Serves as a precursor or ligand in the development of new catalytic systems for stereoselective synthesis.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Material Science Research: Investigated as a monomer or precursor for novel polymers and functional materials with specific electronic properties.

Basic Information

Product Name	(3R)-3-Amino-4,5-Dihydrothiophene-2(3H)-One
CAS No.	130548-06-0
Molecular Formula	C4H7NOS
Molecular Weight	117.17 g/mol
Synonyms	(R)-3-Amino-4,5-dihydrothiophen-2(3H)-one; (3R)-3-Amino-4,5-dihydro-2(3H)-thiophenone; (R)-3-Aminodihydrothiophen-2(3H)-one; (R)-3-Amino-2,3-dihydrothiophen-2-one; (R)-Amino-dihydro-thiophenone; (R)-ADTO; (R)-3-ADT; 2(3H)-Thiophenone, 3-amino-4,5-dihydro-, (3R)-
EINECS	Contact for details

Quality Control

Our (3R)-3-Amino-4,5-Dihydrothiophene-2(3H)-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.