Description

(S)-3-Mercapto-Pyrrolidine-1-Carboxylic Acid Benzyl Ester is a high-purity chiral building block of significant importance in advanced organic synthesis. Its core value lies in the protected mercapto group and the stereogenic center, which are critical for constructing complex molecules with defined three-dimensional structures. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications such as peptidomimetics, enzyme inhibitors, and novel active ingredient discovery.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of protease inhibitors, particularly cysteine protease inhibitors, and other bioactive molecules.
• Peptidomimetic Chemistry: Used to introduce thiol-containing pyrrolidine scaffolds into peptide backbones to modulate stability, activity, and bioavailability.
• Ligand Synthesis: Building block for creating chiral ligands used in asymmetric catalysis.
• Agrochemical Research: Intermediate in the synthesis of novel herbicides, fungicides, or plant growth regulators with specific chiral activity.
• Chemical Biology Probes: Utilized to develop activity-based probes for studying enzyme function and mechanism.
• Material Science: Potential monomer or cross-linker precursor for specialized polymers.

Basic Information

Product Name	(S)-3-Mercapto-Pyrrolidine-1-Carboxylic Acid Benzyl Ester
CAS No.	130516-23-3
Molecular Formula	C12H15NO2S
Molecular Weight	237.32 g/mol
Synonyms	(S)-1-(Benzyloxycarbonyl)-3-mercaptopyrrolidine; (S)-1-Cbz-3-mercaptopyrrolidine; (S)-N-Cbz-3-mercaptopyrrolidine; (S)-3-Mercaptopyrrolidine-1-carboxylic acid benzyl ester; Benzyl (S)-3-mercaptopyrrolidine-1-carboxylate; (S)-3-Mercapto-1-[(phenylmethoxy)carbonyl]pyrrolidine; (S)-1-[(Benzyloxy)carbonyl]-3-mercaptopyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-3-Mercapto-Pyrrolidine-1-Carboxylic Acid Benzyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and process development. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. This compound is easily oxidized and moisture-sensitive; allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.