Description

2,3,4,6-Di-o-Isopropylidene-β-D-Mannopyranose is a protected sugar derivative, a key chiral intermediate in organic synthesis. Its value lies in providing a rigid, non-reactive scaffold that allows for selective functionalization of the mannose sugar ring. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the synthesis of nucleoside analogs, antiviral agents, and complex carbohydrates.

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis of antiviral and anticancer nucleoside drugs.
• Carbohydrate Chemistry: Used in the preparation of complex oligosaccharides, glycoconjugates, and glycomimetics for biological studies.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material for the production of enantiomerically pure compounds.
• Glycobiology Research: A precursor for labeled sugar derivatives used in metabolic pathway tracing and imaging studies.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Diagnostic Reagent Development: Used in creating substrates and probes for enzymatic assays related to carbohydrate metabolism.

Basic Information

Product Name	2,3,4,6-Di-o-Isopropylidene-β-D-Mannopyranose
CAS No.	130495-48-6
Molecular Formula	C12H20O6
Molecular Weight	260.28 g/mol
Synonyms	1,2:5,6-Di-O-Isopropylidene-α-D-Mannofuranose; Diacetone Mannose; 1,2:5,6-Di-O-(1-Methylethylidene)-α-D-mannofuranose; D-Mannose Diethylidene Acetal; 2,3:5,6-Di-O-Isopropylidene-D-mannofuranose; Isopropylidene Mannose; Di-O-isopropylidene-mannofuranose
EINECS	Contact for details

Quality Control

Our 2,3,4,6-Di-o-Isopropylidene-β-D-Mannopyranose is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical R&D and production. A Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]²⁰D	-18° to -22° (c=1 in CHCl₃)
Melting Point	119°C - 123°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.