Description

Glutamate Thiol CAS NO 130306-98-8 is a specialized organosulfur compound that serves as a key intermediate in advanced organic synthesis and pharmaceutical research. Its unique structure, featuring both thiol and glutamate functionalities, makes it a valuable building block for creating complex molecules with targeted biological activity. This high-purity chemical is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors developing novel active ingredients and ligands.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting neurological pathways or acting as enzyme inhibitors.
• Bioconjugation & Protein Modification: Utilized for site-specific labeling of proteins, antibodies, and peptides via thiol-reactive chemistry, enabling the development of diagnostics and biotherapeutics.
• Ligand Synthesis for Catalysis: Serves as a building block for creating chiral ligands used in asymmetric catalysis, enhancing the efficiency and selectivity of chemical transformations.
• Research & Development: Employed in academic and industrial R&D for studying thiol-disulfide exchange reactions and redox biology.
• Agrochemical Synthesis: Used in the development of new crop protection agents and herbicides that leverage its reactive thiol group.
• Material Science: A monomer or cross-linking agent in the synthesis of functional polymers with specific adhesion or responsive properties.

Basic Information

Product Name	Glutamate Thiol
CAS No.	130306-98-8
Molecular Formula	C5H9NO4S
Molecular Weight	179.19 g/mol
Synonyms	L-Glutamic acid, thiol derivative; (2R)-2-Amino-4-mercapto-4-oxobutanoic acid; 2-Amino-4-mercapto-4-oxobutanoic acid; Glutathione precursor intermediate; Thiolated glutamate; Mercaptoglutamic acid derivative
EINECS	Contact for details

Quality Control

Our Glutamate Thiol is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, impurity profile, and chiral purity. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical and advanced research applications.

Storage

Preserve in a tightly closed container, protected from light. Due to its property of being easily oxidized, long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended to maintain stability and purity. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.