Description

1-Bromomethyl-1,2,3,4-Tetrahydroisoquinoline is a versatile and reactive brominated heterocyclic building block. This compound is of significant value in advanced organic synthesis, particularly for constructing complex nitrogen-containing molecular frameworks. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of tetrahydroisoquinoline-based drug candidates, including potential central nervous system (CNS) agents and antimicrobials.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that incorporate the tetrahydroisoquinoline scaffold.
• Ligand and Catalyst Synthesis: Serves as a precursor for creating specialized nitrogen-donor ligands used in asymmetric catalysis and metal complexation.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Material Science: Potential building block for advanced organic materials and functional polymers.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales.

Basic Information

Product Name	1-Bromomethyl-1,2,3,4-Tetrahydroisoquinoline
CAS No.	130109-95-4
Molecular Formula	C10H12BrN
Molecular Weight	226.11 g/mol
Synonyms	1-(Bromomethyl)-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-1-isoquinolinemethyl Bromide; N-(Bromomethyl)-1,2,3,4-tetrahydroisoquinoline; (1,2,3,4-Tetrahydroisoquinolin-1-yl)methyl Bromide; 1-Bromomethyl-THIQ; THIQ-CH2Br; Isoquinoline, 1,2,3,4-tetrahydro-1-(bromomethyl)-
EINECS	Contact for details

Quality Control

Our 1-Bromomethyl-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of our global customer base in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.